Oxandrolone (brand names Oxandrin, Anavar, Lonavar, others), is a synthetic, orally active anabolic-androgenic steroid (AAS) that first became available as a prescription drug in the United States in 1964. It is a 17Î±-methylated derivative of dihydrotestosterone (DHT) that has an oxygen atom in place of the carbon at the 2 position.
Researchers and medical professionals have used oxandrolone to treat a wide variety of disorders. These include idiopathic short stature, Turner syndrome, body mass loss from catabolic illness or long-term corticosteroid treatment, severe burns, surgical or general trauma, osteoporosis, anemia, hereditary angioedema, HIV/AIDS-induced wasting, alcoholic hepatitis, and hypogonadism.
Oxandrolone is well-established as a safe treatment for patients recovering from severe burns. Medical research has also established oxandrolone's efficacy in aiding the development of girls with Turner syndrome. Although oxandrolone has long been used to accelerate growth in children with idiopathic short stature, it is unlikely to increase adult height and in some cases may even decrease it. Oxandrolone has therefore largely been replaced by growth hormone for this use.
Some bodybuilders use oxandrolone for its muscle-building properties, usually purchasing it from black market suppliers. This is illegal in the United States, Canada, the United Kingdom, and many other countries.
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