Anastrozole has been tested for reducing estrogens, including estradiol, in men. Excess estradiol in men can cause benign prostatic hyperplasia, gynecomastia, and symptoms of hypogonadism. It can also contribute to increased risk of stroke, heart attack, chronic inflammation, prostate enlargement and prostate cancer. Some athletes and body builders use anastrozole as part of their steroid cycle to reduce and prevent symptoms of excess estrogen-gynecomastia, emotional lability and water retention. Study data suggests dosages of 0.5mg to 1 mg a day reduce serum estradiol by approximately 50% in men, which differs in postmenopausal women.
Anastrozole is also called Arimidex. It is a type of hormone therapy called an aromatase inhibitor. Anastrozole treats advanced breast cancer in women who have had their menopause.
Anastrozole lowers the amount of oestrogen in the body. The female sex hormones oestrogen and progesterone stimulate many breast cancers to grow. Lowering the level of oestrogen can stop or slow the growth of breast cancer cells.
Anastrozole blocks a process called aromatisation which changes sex hormones called androgens into oestrogen. This happens mainly in the fatty tissues, muscle and the skin and needs a particular enzyme called aromatase.
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